Alzheimer’s Disease classification Using Bilateral Residual Adaptive Intelligent Multiclass Network
Keywords:
Alzheimer’s Disease, Cognitive Impairment, Early Diagnosis, Magnetic Resonance Imaging, Medical Recommendation, Multiclass PredictionAbstract
Early Alzheimer's disease (EAD) diagnosis enables individuals to take preventative actions before irreversible brain damage occurs. Cross-sectional imaging studies of AD demonstrate that the characteristics of the abrasion sites in AD patients, as revealed by magnetic resonance imaging (MRI), are highly diverse and distributed across the image space. In AD memory and cognitive abilities deteriorate, affecting the capacity to do basic activities. In and around brain cells, aberrant amyloid and tau protein accumulation is believed to cause it. Amyloid deposits create plaques surrounding brain cells, whereas tau deposits form tangles inside brain cells. The plagues and tangles harm healthy brain cells, causing shrinkage. This damage seems to be occurring in the hippocampus, a brain region involved in memory formation. There are presently no methods that provide the most accurate outcomes and suggestions. The current techniques do not identify AD early. So, we proposed Bilateral Residual Adaptive Intelligent Multiclass Network (BRAIM-Net) method for identifying the earlier prediction of AD. In BRAIM-Net, two datasets are used, namely an MRI image dataset and a text dataset. The MRI image dataset has been trained with CNN-deep residual network (ResNet) layers. Deep ResNet enables this ResNet model to extract more information from network levels. The Modified Adam Optimization has selected the best feature information from MRI scans of Alzheimer's patients and transferred it to another area while keeping the most important data. Using the BRAIM-Net approach, a multiclass classification has been carried out. Finally, users can enter their queries and the system will retrieve medical advice. The experimental results indicate that the classification accuracy of the approach proposed in this research can reach 97.86%..
Downloads
References
[1] K. Gasmi, A. Alyami, O. Hamid, M. O. Altaieb, O. R. Shahin, L. Ben Ammar, H. Chouaib, and A. Shehab, “Optimized hybrid deep learning framework for early detection of Alzheimer’s disease using adaptive weight selection,” Diagnostics, vol. 14, no. 24, Art. no. 2779, 2024, doi: 10.3390/diagnostics14242779.
[2] M. El-Assy, H. M. Amer, H. M. Ibrahim, et al., “A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI data,” Scientific Reports, vol. 14, Art. no. 3463, 2024, doi: 10.1038/s41598-024-53733-6.
[3] S. E. Sorour, A. A. Abd El-Mageed, K. M. Albarrak, A. K. Alnaim, A. A. Wafa, and E. El-Shafeiy, “Classification of Alzheimer’s disease using MRI data based on deep learning techniques,” Journal of King Saud University - Computer and Information Sciences, vol. 36, no. 2, Art. no. 101940, 2024, doi: 10.1016/j.jksuci.2024.101940.
[4] S. Odimayo, C. C. Olisah, and K. Mohammed, “Structure focused neurodegeneration convolutional neural network for modelling and classification of Alzheimer’s disease,” Scientific Reports, vol. 14, Art. no. 15270, 2024, doi: 10.1038/s41598-024-60611-8.
[5] M. Alruily, A. A. Abd El-Aziz, A. M. Mostafa, M. Ezz, E. Mostafa, et al., “Ensemble deep learning for Alzheimer’s disease diagnosis using MRI: Integrating features from VGG16, MobileNet, and InceptionResNetV2 models,” PLOS ONE, vol. 20, no. 4, Art. no. e0318620, 2025, doi: 10.1371/journal.pone.0318620.
[6] Jenber Belay, Y. M. Walle, and M. B. Haile, “Deep ensemble learning and quantum machine learning approach for Alzheimer’s disease detection,” Scientific Reports, vol. 14, Art. no. 14196, 2024, doi: 10.1038/s41598-024-61452-1.
[7] S. Dardouri, “An efficient method for early Alzheimer’s disease detection based on MRI images using deep convolutional neural networks,” Frontiers in Artificial Intelligence, vol. 8, Art. no. 1563016, 2025, doi: 10.3389/frai.2025.1563016.
[8] S. B. Shahid, M. Kaikaus, M. H. Kabir, M. A. Yousuf, A. K. M. Azad, A. S. Al-Moisheer, N. Alotaibi, S. A. Alyami, T. Bhuiyan, and M. A. Moni, “Novel deep learning for multi-class classification of Alzheimer’s in disability using MRI datasets,” Frontiers in Bioinformatics, vol. 5, Art. no. 1567219, 2025, doi: 10.3389/fbinf.2025.1567219.
[9] S. M. Mousavi, K. Moulaei, and L. Ahmadian, “Classifying and diagnosing Alzheimer’s disease with deep learning using 6735 brain MRI images,” Scientific Reports, vol. 15, Art. no. 22721, 2025, doi: 10.1038/s41598-025-08092-1.
[10] H. Segmen and M. Yildiz, “A multi-locus and machine learning-based assessment of SNCA variants in Alzheimer’s disease,” International Journal of Molecular Sciences, vol. 27, no. 11, Art. no. 5143, 2026, doi: 10.3390/ijms27115143.
[11] Y. M. Elgammal, M. A. Zahran, and M. M. Abdelsalam, “A new strategy for the early detection of Alzheimer disease stages using multifractal geometry analysis based on K-nearest neighbor algorithm,” Scientific Reports, vol. 12, no. 1, Art. no. 22381, 2022.
[12] D. Dana and A. Alashqur, “Using decision tree classification to assist in the prediction of Alzheimer’s disease,” in Proc. 6th Int. Conf. Computer Science and Information Technology (CSIT), 2014, pp. 122–126.
[13] Mehmood, M. Maqsood, M. Bashir, and Y. Shuyuan, “A deep Siamese convolution neural network for multi-class classification of Alzheimer disease,” Brain Sciences, vol. 10, no. 2, Art. no. 84, 2020.
[14] M. Song, H. Jung, S. Lee, D. Kim, and M. Ahn, “Diagnostic classification and biomarker identification of Alzheimer’s disease with random forest algorithm,” Brain Sciences, vol. 11, no. 4, Art. no. 453, 2021.
[15] L. V. Fulton, D. Dolezel, J. Harrop, Y. Yan, and C. P. Fulton, “Classification of Alzheimer’s disease with and without imagery using gradient boosted machines and ResNet-50,” Brain Sciences, vol. 9, no. 9, Art. no. 212, 2019.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Articles published in the Academic Research Journal of Science and Technology (ARJST will be Open-Access articles distributed under the terms and conditions of the Creative Commons Attribution-Noncommercial 4.0 International (CC BY-NC 4.0). This allows for immediate free access to the work and permits any user to read, download, copy, distribute, print, search, or link to the full texts of articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose.
This open-access article is distributed under the terms and conditions of the Creative Commons Attribution-Noncommercial 4.0 International (CC BY-NC 4.0).